Date

2025-07-25

Protocol

Protocol changed

Item Changed

Secondary outcome(s) - Time of assessment(s)

Previous Version

1. Annualized Rate of change in eGFRb (ie., annualized eGFR total slope) 2. Serum galactose deficient IgA1 (Gd-IgA1) levels Composite kidney failure endpoint defined as experiencing at least one of the following during the study: • At least a 30% reduction in eGFR sustained for at least 30 days • eGFR <15 mL/min/1.73m2 sustained for at least 30 days • Chronic dialysis ?30 days • Kidney transplantation • Death from kidney failure [1. Baseline,Week 52, 104; 2.Baseline, Weeks 36, 52, and 104; 3.Over 104 weeks]

Next Version

Annualized rate of change in eGFRb (i.e., annualized eGFR total slope) [Through Week 104]